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Akihiro Yachie Selected Research

Interleukin-18 (Interleukin 18)

4/2022Repeated Necrotizing Lymphadenitis with MEFV Gene Mutations.
1/2021Clinical significance of interleukin-18 for the diagnosis and prediction of disease course in systemic juvenile idiopathic arthritis.
1/2021Comparison of serum cytokine profiles in macrophage activation syndrome complicating different background rheumatic diseases in children.
9/2020The possession of exon 2 or exon 3 variants in the MEFV gene promotes inflammasome activation in Japanese patients with familial Mediterranean fever with a heterozygous exon 10 mutation.
1/2020Cytokine Profiles in Human Parechovirus Type 3-induced Sepsis-like Syndrome.
1/2020Interleukin-18 and fibroblast growth factor 2 in combination is a useful diagnostic biomarker to distinguish adult-onset Still's disease from sepsis.
10/2019Macrophage activation syndrome in neonates born to mothers with adult-onset Still's disease: Perinatal effect of maternal IL-18.
12/2018A case of incomplete Kawasaki disease with extremely high serum ferritin and interleukin-18 levels.
10/2018Transient natural killer cell dysfunction associated with interleukin-18 overproduction in systemic juvenile idiopathic arthritis.
1/2018Longitudinal analysis of serum interleukin-18 in patients with familial Mediterranean fever carrying MEFV mutations in exon 10.
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Akihiro Yachie Research Topics

Disease

27Juvenile Arthritis (Juvenile Idiopathic Arthritis)
01/2021 - 09/2010
17Macrophage Activation Syndrome
01/2021 - 09/2010
13Inflammation (Inflammations)
01/2021 - 12/2006
12Infections
03/2020 - 12/2005
10Hemolytic-Uremic Syndrome
12/2021 - 10/2012
10Mucocutaneous Lymph Node Syndrome (Kawasaki Disease)
01/2021 - 09/2010
9Familial Mediterranean Fever (Periodic Disease)
10/2021 - 11/2010
9Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome)
12/2020 - 01/2011
8Fever (Fevers)
12/2020 - 12/2005
7Neoplasms (Cancer)
03/2020 - 04/2003
6Proteinuria
01/2021 - 10/2005
6Arthritis (Polyarthritis)
11/2019 - 09/2003
5Adult-Onset Still's Disease
01/2020 - 06/2012
5Glioblastoma (Glioblastoma Multiforme)
08/2019 - 05/2010
5Epstein-Barr Virus Infections
04/2018 - 12/2006
5Brain Diseases (Brain Disorder)
12/2017 - 12/2012
4Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
11/2021 - 01/2010
4Sepsis (Septicemia)
10/2021 - 01/2011
4Disease Progression
07/2018 - 01/2011
4Nephrotic Syndrome (Syndrome, Nephrotic)
06/2018 - 05/2013
4Hemolysis
08/2014 - 08/2002
4Anemia
08/2014 - 01/2002
4Glioma (Gliomas)
01/2014 - 05/2010
4Atherosclerosis
11/2005 - 08/2002
3Erythema
11/2021 - 12/2005
3Human Influenza (Influenza)
01/2021 - 10/2012
3Edema (Dropsy)
12/2018 - 05/2014
3Thrombocytopenia (Thrombopenia)
08/2018 - 04/2014
3Rheumatoid Arthritis
07/2018 - 09/2003
3Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
01/2017 - 04/2003
3Colitis
09/2016 - 05/2012
3Wiskott-Aldrich Syndrome
02/2013 - 12/2002
2Cytokine Release Syndrome
01/2021 - 02/2013
2Nephritis
01/2021 - 01/2011
2Hematuria
01/2021 - 10/2005
2IGA Glomerulonephritis (IGA Nephropathy)
01/2021 - 01/2020
2Bacterial Infections (Bacterial Infection)
03/2020 - 05/2014
2Polyarteritis Nodosa (Periarteritis Nodosa)
01/2020 - 01/2017
2Systemic Lupus Erythematosus (Libman-Sacks Disease)
11/2019 - 02/2013
2Necrosis
01/2019 - 12/2012
2Exanthema (Rash)
12/2018 - 02/2013
2Aplastic Anemia (Anemia, Hypoplastic)
08/2018 - 06/2011
2Hypoxia (Hypoxemia)
12/2017 - 09/2014
2Brain Neoplasms (Brain Tumor)
12/2017 - 03/2013
2Tubulointerstitial nephritis and uveitis
05/2016 - 03/2013
2Enterocolitis
01/2016 - 10/2014
2Lymphoma (Lymphomas)
01/2016 - 03/2002
2Bites and Stings (Sting)
08/2015 - 12/2009
2Renal Insufficiency (Renal Failure)
01/2015 - 08/2002

Drug/Important Bio-Agent (IBA)

30CytokinesIBA
10/2021 - 02/2005
20Interleukin-18 (Interleukin 18)IBA
04/2022 - 09/2010
19Biomarkers (Surrogate Marker)IBA
12/2021 - 12/2002
13InterleukinsIBA
01/2020 - 01/2011
11Interleukin-6 (Interleukin 6)IBA
01/2021 - 04/2007
9NeopterinIBA
01/2021 - 04/2007
9Rituximab (Mabthera)FDA Link
06/2018 - 12/2006
8EnzymesIBA
01/2022 - 12/2006
8Proteins (Proteins, Gene)FDA Link
08/2019 - 04/2003
7Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
12/2021 - 12/2012
6Indicators and Reagents (Reagents)IBA
12/2021 - 01/2011
6tocilizumab (atlizumab)FDA Link
12/2020 - 05/2012
5Immunoglobulins (Immunoglobulin)IBA
10/2020 - 01/2009
5Immunoglobulin E (IgE)IBA
01/2016 - 11/2006
5IronIBA
08/2014 - 01/2002
4SteroidsIBA
12/2020 - 05/2012
4ImmunosorbentsIBA
01/2020 - 06/2015
4Adrenal Cortex Hormones (Corticosteroids)IBA
08/2019 - 09/2003
4Ferritins (Ferritin)IBA
12/2018 - 01/2002
4DNA (Deoxyribonucleic Acid)IBA
01/2017 - 04/2003
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2021 - 09/2016
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2021 - 12/2017
3CannabinoidsIBA
08/2019 - 10/2012
3Interleukin-33IBA
04/2019 - 05/2013
3HLA-DR Antigens (HLA-DR)IBA
06/2018 - 06/2010
3AntigensIBA
07/2017 - 12/2005
3Etanercept (Enbrel)FDA Link
01/2017 - 01/2011
3Heme Oxygenase-1IBA
08/2014 - 10/2005
2LipopolysaccharidesIBA
12/2021 - 01/2018
2Methotrexate (Mexate)FDA LinkGeneric
11/2021 - 09/2003
2Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
10/2021 - 01/2020
2InflammasomesIBA
11/2020 - 09/2020
2Pharmaceutical PreparationsIBA
03/2020 - 12/2005
2Anti-Bacterial Agents (Antibiotics)IBA
11/2019 - 09/2003
2Messenger RNA (mRNA)IBA
08/2019 - 10/2005
2Cannabinoid Receptors (Cannabinoid Receptor)IBA
08/2019 - 10/2012
2EndocannabinoidsIBA
08/2019 - 12/2017
2TheobromineIBA
05/2019 - 01/2014
2Leucine (L-Leucine)FDA Link
01/2019 - 09/2017
2Immunosuppressive Agents (Immunosuppressants)IBA
06/2018 - 12/2006
2HLA Antigens (Human Leukocyte Antigens)IBA
04/2018 - 06/2010
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
12/2017 - 10/2013
2Rheumatoid FactorIBA
07/2017 - 09/2003
2Angiopoietin-1IBA
02/2017 - 04/2016
2AngiopoietinsIBA
02/2017 - 04/2016
2MethylprednisoloneFDA LinkGeneric
07/2016 - 06/2014
2Immunoglobulin A (IgA)IBA
04/2015 - 02/2013

Therapy/Procedure

13Therapeutics
12/2020 - 12/2006
5Bone Marrow Transplantation (Transplantation, Bone Marrow)
07/2017 - 12/2002
4Drug Therapy (Chemotherapy)
03/2020 - 09/2012
4Transplantation
08/2018 - 04/2003